{"id":51,"date":"2018-11-05T17:32:43","date_gmt":"2018-11-05T17:32:43","guid":{"rendered":"https:\/\/livonlabs.hk\/?page_id=51"},"modified":"2018-11-08T07:49:27","modified_gmt":"2018-11-08T07:49:27","slug":"science","status":"publish","type":"page","link":"https:\/\/livonlabs.gogo2hk.com\/en\/science\/","title":{"rendered":"Studies and Resources"},"content":{"rendered":"  <div id=\"page-header-1100828611\" class=\"page-header-wrapper\">\n  <div class=\"page-title dark featured-title\">\n\n    \n    <div class=\"page-title-inner container align-top text-center flex-row-col medium-flex-wrap\" >\n              <div class=\"title-wrapper flex-col\">\n          <h1 class=\"entry-title mb-0\">\n            Studies and Resources          <\/h1>\n        <\/div>\n                    <div class=\"title-content flex-col\">\n        <div class=\"title-breadcrumbs pb-half pt-half\"><\/div>      <\/div>\n    <\/div>\n\n     \n<style>\n#page-header-1100828611 .page-title-inner {\n  min-height: 0px;\n}\n<\/style>\n  <\/div>\n    <\/div>\n  \n<h2>References\/Citations\/Summaries<\/h2>\n<p>\u00a0<\/p>\n<div><strong>Gropper SS, Smith JL, Groff JL, (2009), Advanced Nutrition and Human Metabolism, West Publishing Co. p 313.<\/strong><\/p>\n<p>Vitamin C [non-liposomal] bioavailability decreases with dose size<br \/>As dose size increases, bioavailabiity decreases dramatically. The authors express this finding by stating that 98% of a 20 mg oral dose of [non-liposome-encapsulated] vitamin C is bioavailable (enters the bloodstream) whereas only 16% of a 12,000 mg dose does so.<\/p>\n<\/div>\n<hr \/>\n<div><strong>Gerster H, (1987), Human vitamin C requirements, Z Ernahrungswiss. Jun;26(2):125-37.<\/strong><\/p>\n<p>Based on previous recommended daily allowance (RDA) studies by the National Institutes of Health, author suggests that a 200 mg daily intake of vitamin C is sufficient to provide tissue saturation. By implication, any additional vitamin C would not be used or bioavailable. He does also suggest that smokers and those in disease states may have a higher requirement for vitamin C. [NOTE: Hickey &amp; Roberts (2004) debunk the flawed nature of these NIH studies]\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3307183#\" target=\"_blank\" rel=\"noopener\">VIEW ABSTRACT<\/a><\/div>\n<hr \/>\n<div><strong>Hickey S., Roberts H, Miller N, (2008), &#8220;Pharmacokinetics of oral vitamin C&#8221; Journal of Nutritional &amp; Environmental Medicine July 31.<\/strong><\/p>\n<p>Authors found that a liposome-encapsulated vitamin C nearly doubled bioavailability over that thought possible from studies published by the National Institutes of Health.<\/p>\n<p><a href=\"https:\/\/www.livonlabs.com\/proof\/Dr_Hickey_Clinical_Study_Published.pdf\" target=\"_blank\" rel=\"noopener\">VIEW STUDY<\/a><\/div>\n<hr \/>\n<div><strong>Hickey S, Roberts H, (2004), Ascorbate: The Science of Vitamin C, 2004.<\/strong><\/p>\n<p>This book presents a new model, describing the action of vitamin C in health. It demonstrates conclusively that the establishment has misinterpreted the evidence. The dynamic flow model explains the current results and points the way for future experiments. This book is a must for people who want to understand the scientific evidence and support for high-dose vitamin C.<\/p>\n<\/div>\n<hr \/>\n<div><strong>Kelly C, Jefferies C, Cryan SA, (2011), &#8220;Targeted liposomal drug delivery to monocytes and macrophages,&#8221; J Drug Deliv.<\/strong><\/p>\n<p>Liposomes can be used to effectively deliver therapeutic agents particular cell types (mononuclear phagocytic system, particularly macrophages). These cells are of particular importance in the immune system.<\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21512579#\" target=\"_blank\" rel=\"noopener\">VIEW ABSTRACT<\/a><\/div>\n<hr \/>\n<div><strong>Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, Dhariwal KR, Park JB, Lazarev A, Graumlich JF, King J, Cantilena LR. (1996), &#8220;Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance,&#8221; Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3704-9..<\/strong><\/p>\n<p>Authors report very rapid decline in bioavailability [of non-liposome-encapsulated vitamin C] with dose size. The &#8220;steep portion of the curve&#8221; starts between 30 mg and 100 mg of daily dose. Based on their findings, they suggest that &#8220;vitamin C daily doses above 400 mg have no evident value.&#8221; This conclusion is based on the faulty presupposition that the appearance of vitamin C in the urine indicates all bodily tissues are saturated and the body requires no additional vitamin C. This assumption is clearly refuted by Hickey, et al. in his book Ascorbate: The Science of Vitamin C referenced above.<\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8623000#\" target=\"_blank\" rel=\"noopener\">VIEW ABSTRACT<\/a><\/div>\n<hr \/>\n<div><strong>Mitsopoulos P, Suntres ZE, (2011), &#8220;Protective Effects of Liposomal N-Acetylcysteine against Paraquat-Induced Cytotoxicity and Gene Expression,&#8221; J Toxicol.<\/strong><\/p>\n<p>N-acetylcysteine (NAC) was encapsulated in liposomes and administered as a trea\u2122ent for paraquat poisoning. Pretrea\u2122ent with this liposomal NAC was found to be more effective than conventional drugs in reducing the effects of paraquat poisoning.<\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21584258#\" target=\"_blank\" rel=\"noopener\">VIEW ABSTRACT<\/a><\/div>\n<hr \/>\n<div><strong>Parmentier J, Thewes B, Gropp F, Fricker G, (2011), &#8220;Oral peptide delivery by tetraether lipid liposomes,&#8221; Int J Pharm. Jun 2.<\/strong><\/p>\n<p>Liposomes were used to deliver peptides agents which normally break down in the stomach. Bioavailability in some tests improved by 460%.<\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21664955#\" target=\"_blank\" rel=\"noopener\">VIEW ABSTRACT<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>References\/Citations\/Summaries \u00a0 Gropper SS, Smith JL, Groff JL, (2009), Advanced Nutrition and Human Metabolism, West Publishing Co. p 313. Vitamin C [non-liposomal] bioavailability decreases with dose sizeAs dose size increases, bioavailabiity decreases dramatically. The authors express this finding by stating that 98% of a 20 mg oral dose of [non-liposome-encapsulated] vitamin C is bioavailable (enters<\/p>\n","protected":false},"author":0,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-51","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Lypo-Spheric Vitamin C \u8102\u8cea\u9ad4\u7dad\u4ed6\u547dC - Livonlabs \u8102\u8cea\u9ad4\u71df\u990a\u88dc\u5145\u54c1<\/title>\n<meta name=\"description\" content=\"Lypo-Spheric Vitamin C, \u8102\u8cea\u9ad4\u7dad\u4ed6\u547dC, lypricel, \u8102\u8cea\u6027, Liposomal vitamin C, Liposomal Glutathione, \u8102\u8cea\u9ad4\u7a40\u80f1\u7518\u80bd , Liposomal R-Alpha-Lipoic-Acid \u8102\u8cea\u9ad4R-\u786b\u8f9b\u9178, Liposomal Vitamin B complex \u8102\u8cea\u9ad4\u7dad\u751f\u7d20B\u7fa4, Liposomal Magnesium Threonate , \u8102\u8cea\u9ad4\u8607\u7cd6\u9178\u9382\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/livonlabs.gogo2hk.com\/en\/science\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Lypo-Spheric Vitamin C \u8102\u8cea\u9ad4\u7dad\u4ed6\u547dC - 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